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Modified Photochemical Properties of Mitoxantrone by Plasmonic Photothermal Response of Hollow Gold Nanoshells
Introduction: Mitoxantrone (MX) has been introduced as a photosensitizer drug. However, due to some side effects, the widespread use of this drug has been confronted with some limitations. Hollow gold nanoshells (HGN) have attracted considerable attention due to their interesting photochemical features that can use as nanocarrier. In this paper, the thermal response of MX and the use of this pr...
متن کاملComparative Evaluation of Mx and Alum as Bio and Conventional Adjuvants in Inducing Immune Responses by Influenza DNA Vaccine
Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated. Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...
متن کاملHigh-performance message-passing over generic Ethernet hardware with Open-MX
In the last decade, cluster computing has become the most popular high-performance computing architecture. Although numerous technological innovations have been proposed to improve the interconnection of nodes, many clusters still rely on commodity Ethernet hardware to implement message passing within parallel applications. We present Open-MX, an open-source message passing stack over generic E...
متن کاملCINEMA-MX: a modular multiple alignment editor
UNLABELLED Analyzing and visualizing multiple sequence alignments is a common task in many areas of molecular biology and bioinformatics. Many tools exist for this purpose, but are not easily customizable for specific in-house uses. Here we report the development of an editor, CINEMA-MX, that addresses these issues. CINEMA-MX is highly modular and configurable, and we present examples to illust...
متن کاملMultidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.
Based upon several previous reports, no consistent relationship between multidrug resistance protein 1 (MRP1, ABCC1) expression and cellular sensitivity to mitoxantrone (MX) toxicity can be ascertained; thus, the role of MRP1 in MX resistance remains controversial. The present study, using paired parental, MRP1-poor, and transduced MRP1-overexpressing MCF7 cells, unequivocally demonstrates that...
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